NF Kappa B

More on Vitamin D3 and CFS

Vitamin D3 is regulated by P450 enzyme systems that are in turn decoupled due to low NADPH levels in CFS. This raises important questions regarding the reasons that may underlie low D3 levels typical for most CFS cases. The finding of increased intracellular calcium by UK investigators may also play into the reasons for finding low D3 in CFS. Given these deeper issues that may underlie D3 levels suggests that aggressive D3 therapy may not be the best course of action in CFS. D3 is a highly regulated pro-hormone and there could be good reasons for it to be down-regulated in CFS.

Curcumin – an herb for all seasons

Curcumin is a member of a class of complex biochemicals known as curcuminoids and the principal constituent of the spice known as turmeric and responsible for its yellow color. In turn, turmeric is the principal spice in common yellow curry powder which can contain many spices that vary widely among popular cuisines. Curcumin contains polyphenols that have significant medicinal properties and used historically in southeastern Asia and India and commonly used in Ayurvedic medicine. Turmeric is a perennial herb and member of the ginger family and native to tropical southeast Asia. Heavy curcumin use in India is thought to explain, in part, the low incidence of Alzheimers disease as it is anti-inflammatory and an antioxidant and promotes neurogenesis. It is also anti-bacterial and anti-viral as well as having anti-cancer properties and heavy metal chelation properties, especially iron.

Artemisins as therapy in CFS

Before we learned that Artesunate might inhibit XMRV via NF Kappa B inhibition in August of 2009, we were aware that Artesunate was a known inhibitor of all known human herpes viruses against which it has been tested as well as HIV. I was first introduced to Artesunate by a prominent Autism expert at a medical conference who finds it helpful in Autism. We were also impressed that Artesunate and its relative Wormwood, using SL administration on the echo table, produced the most powerful ablation of oxygen toxicity as well as the ablation of other echo terrain map (ETM) backflashes than any other therapy we have ever used. Both Artesunate and Wormwood will do this in 30 seconds.

XMRV and its intracellular toxicity based on redox shifts

There are ways that retroviruses can impact the cell the I believe are especially important to CFS and data exists to support these assertions both in the literature (see below) and in such findings as low SOD and GPx in CFS and provides a mechanism to explain oxygen toxicity by ETM which is nearly universal in CFS.

Infectious and Therapeutic Issues to consider in XMRV infection now linked to CFS

Proper buffering of the redox set point for the human body’s biological terrain is critical to control intracellular viral replication. Oxidative stess will potentially amplify XMRV replication. The biggest amplifier of oxidative stress due to any cause is NF Kappa B and one of the best inhibitors of NF-kB are the artemisins (Artesunate and Wormwood). Artemisins are also thought to be useful in cancer. We will be exploring the dose response curve for Artemisins to inhibit infectious XMRV in the near future to determine the best dose. We already know that activating NF-kB activates this virus and suppressing NF-kB inhibits XMRV. Artesunate is also known to inhibit HIV and all the associated herpes viruses that are co-factors in the evolution of AIDS and CFS as well.

Artesunate Complications

This discussion explores the potential complications of Artesunate with two examples cited in patients.

Oxidative Therapies vs. Anti-Oxidative Therapies

In this discussion, Dr. Cheney explores the opposite approaches of anti-oxidative vs. pro-oxidative therapies. It is important to recognize that both may be useful but in the highly oxidizing environment of CFS, one may be more appropriate than the other and much safer.