NADPH

More on Vitamin D3 and CFS

Vitamin D3 is regulated by P450 enzyme systems that are in turn decoupled due to low NADPH levels in CFS. This raises important questions regarding the reasons that may underlie low D3 levels typical for most CFS cases. The finding of increased intracellular calcium by UK investigators may also play into the reasons for finding low D3 in CFS. Given these deeper issues that may underlie D3 levels suggests that aggressive D3 therapy may not be the best course of action in CFS. D3 is a highly regulated pro-hormone and there could be good reasons for it to be down-regulated in CFS.

Anabolism vs. Catabolism – an issue of timing

When deciding when to use the CSF mixtures, hereafter called the Catabolic CSF Mixture (Heart, Brain and Pancreas) and the Anabolic CSF Mixture (Pancreas, Liver and Kidney), it is important to understand or “grok” your own catabolic period and your own anabolic period of the day.

Catabolism and Anabolism in respect to hormones

What is so interesting in CFS is that the body realizes that in favoring “catabolism” requires that there be immunosuppression lest there be too much oxidative stress and when favoring “anabolism” there can be immunactivation as the oxidative stress is under better control if you combine anabolism (aka NADPH and increased GSH) with immunoactivation. The exceptions appear to be estrogen and progesterone, at least on ETM, and my guess is that they are not as catabolically or anabolically active as Cortisol and DHEA, respectively, but are very immunoactive. What is not as clear to me is whether Vitamin D is “catabolic” and Melatonin is “anabolic”.