Diastolic Dysfunction in CFS

Attached below is an abstract presented at the IACFS meetings in Reno, NV in March 2009. This abstract presents the results of a large (N = 90) study of CFD patients seen at the Cheney Clinic and examines diastolic parameters by echocardiography and compares the results to age and sex matched controls.


I feel strongly that the almost 90% PFO incidence in CFS is largely acquired with the onset of CFS and is not pre-existing except in perhaps 27%. The PFO shunt from right to left will be stronger however, once CFS cardiac physiology is manifest with the near universal (>96%) finding of diastolic dysfunction. I suspect the frequent brain UBO’s on MRI scans are likely a result of this right to left PFO shunting as well as certain symptoms such as migraine and periodic hyperventilation. PFO could also be a factor in sleep apnea pathophysiology. Heavy snoring and airway obstruction is a valsalva maneuver and can cause shunting right to left, particulary if there is also desaturation. Below is an abstract of data on CFS patients at the Cheney Clinic showing an extremely high incidence of PFO using contrast bubble studies.

Echo Terrain Map

The Echo Terrain Map (ETM) is an echocardiograph derived terrain map composed of a series of positive and negative IVRT responses in patients to a sequence of specific interrogations on the echocardiograph table. Reponses to only two interrogations in real time by transdermal gel to two mammalian cell signaling factors (CSF’s derived from porcine Liver and porcine Adrenal) provides a highly sensitive (100%) and specific (100%) diagnosis of classic CFS with disability. Atypical cases can be seen that do not have this classic negative response pattern but their history is also atypical for CFS with disability.

High output heart failure and T3 thyroid hormone in CFS

This case presentation discusses the hazards of aggressive use of the potent T3 thyroid hormone in CFS.